Non-HLA donor-recipient mismatches in kidney transplantation-A stone left unturned.

In kidney transplantation, short-term allograft survival has improved due to improvements in acute rejection episodes without corresponding improvements in long-term survival. Although current organ allocation algorithms take into account human leukocyte antigen (HLA) matching to reduce antidonor alloimmune responses, it is likely that genomic variation at non-HLA loci (ie, non-HLA donor-recipient [D-R] pair mismatches) play a role in the "non-self" responses and ultimately affect long-term allograft survival. Existing data from both animal models and human studies suggest an association between non-HLA D-R mismatches and kidney allograft outcomes. In this minireview, we examine existing and emerging data and discuss putative mechanisms on the role of non-HLA D-R mismatches on long-term allograft outcomes in kidney transplantation. © 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.

Citation

Samira Farouk, Zhongyang Zhang, Madhav C Menon. Non-HLA donor-recipient mismatches in kidney transplantation-A stone left unturned. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2020 Jan;20(1):19-24

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PMID: 31550409

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