Correlation Engine 2.0
Clear Search sequence regions

  • biomaterials (4)
  • humans (1)
  • macrophages (10)
  • therapies (1)
  • Sizes of these terms reflect their relevance to your search.

    Tumor-associated macrophages (TAMs) are a complex and heterogeneous population of cells within the tumor microenvironment. In many tumor types, TAMs contribute toward tumor malignancy and are therefore a therapeutic target of interest. Here, three major strategies for regulating TAMs are highlighted, emphasizing the role of biomaterials in these approaches. First, systemic methods for targeting tumor-associated macrophage are summarized and limitations to both passive and active targeting approaches considered. Second, lessons learned from the significant literature on wound healing and macrophage response to implanted biomaterials are discussed with the vision of applying these principles to localized, biomaterial-based modulation of tumor-associated macrophage. Finally, the developing field of engineered macrophages, including genetic engineering and integration with biomaterials or drug delivery systems, is examined. Analysis of major challenges in the field along with exciting opportunities for the future of macrophage-based therapies in oncology are included. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


    Meilyn Sylvestre, Courtney A Crane, Suzie H Pun. Progress on Modulating Tumor-Associated Macrophages with Biomaterials. Advanced materials (Deerfield Beach, Fla.). 2020 Apr;32(13):e1902007

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 31559665

    View Full Text