Role of Potassium-Sparing Diuretics in the Management of Hypokalemia in Peritoneal Dialysis.

Patients with kidney disease are at a higher risk of experiencing potassium imbalance. The kidney plays an important role in maintaining potassium homeostasis. A common dyskalemia that peritoneal dialysis (PD) patients experience is hypokalemia. Potassium-sparing diuretics such as spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Owing to its potassium-sparing effects, it may correct hypokalemia that PD patients experience. The proper usage of potassium-sparing diuretics in PD patients and data on the efficacy and safety are being explored. Four relevant trials were identified. One randomized double-blind placebo-controlled cross-over study (n = 20), one interventional study without the control group (n = 20), one retrospective single-center chart review (n = 53), and one cross-sectional review (n = 75) trial. The randomized controlled trial did not note a statistically significant change in K levels (P > 0.05); the other 3 trials observed an increase in potassium levels in the potassium-sparing diuretics groups, but trials contained small participants and inadequate statistic rigor. The role of potassium-sparing diuretics use for hypokalemia management in PD patients remains unclear. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Timothy Nguyen, Steven Ren, Jaweria Hussain, Jessica J Balaoro. Role of Potassium-Sparing Diuretics in the Management of Hypokalemia in Peritoneal Dialysis. American journal of therapeutics. 2021 May-Jun 01;28(3):e349-e354

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PMID: 31567176

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