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Tolvaptan is an effective therapy for heart failure patients with symptomatic congestion and hyponatremia. The efficacy of its use in patients with continuous-flow left ventricular assist devices (LVADs) is unknown. The aim of this study was to assess the clinical efficacy and safety of tolvaptan in LVAD patients. We retrospectively reviewed medical records of patients who underwent LVAD implantation between January 2014 and August 2018. Among 217 consecutive LVAD patients, tolvaptan was used in 20 patients. Mean age was 46 ± 14 years old and 14 patients were males. The duration of tolvaptan therapy was 4 (interquartile range 1-8) days. Urine volume significantly increased from 2,623 ± 1,109 ml/day before tolvaptan to 4,308 ± 1,432 ml/day during tolvaptan therapy (p < 0.001). Serum sodium increased from 127 ± 3 to 133 ± 3 mEq/L at the end of tolvaptan therapy (p < 0.001). No patients developed hypernatremia (serum sodium >150 mEq/L). The 90-day overall survival following tolvaptan therapy was 89% in both the tolvaptan group and a propensity score-matched non-tolvaptan group (p = 0.918). Survival free of heart failure readmissions was also comparable between the groups (p = 0.751). In conclusion, short-term use of tolvaptan following LVAD implantation is a safe and effective therapy to augment diuresis and improve hyponatremia.


Takeo Fujino, Teruhiko Imamura, Ann Nguyen, Ben Chung, Jayant Raikhelkar, Daniel Rodgers, Daisuke Nitta, Bryan Smith, Nitasha Sarswat, Sara Kalantari, Nikhil Narang, Colleen LaBuhn, Valluvan Jeevanandam, Gene Kim, Gabriel Sayer, Nir Uriel. Short-Term Efficacy and Safety of Tolvaptan in Patients with Left Ventricular Assist Devices. ASAIO journal (American Society for Artificial Internal Organs : 1992). 2020 Mar;66(3):253-257

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PMID: 31567410

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