Correlation Engine 2.0
Clear Search sequence regions

  • dental pulp (1)
  • dentinogenesis (1)
  • dopamine (12)
  • gene (1)
  • incisors (1)
  • odontoblasts (6)
  • PKA (2)
  • rat (3)
  • receptors (5)
  • Sizes of these terms reflect their relevance to your search.

    Dopamine (DA) is produced from tyrosine by tyrosine hydroxylase (TH). A recent study has reported that DA promotes the mineralization of murine preosteoblasts. However, the role of DA in odontoblasts has not been examined. Therefore, in this investigation, we researched the expression of TH and DA in odontoblasts and the effects of DA on the differentiation of preodontoblasts (KN-3 cells). Immunostaining showed that TH and DA were intensely expressed in odontoblasts and preodontoblasts of rat incisors and molars. KN-3 cells expressed D1-like and D2-like receptors for DA. Furthermore, DA promoted odontoblastic differentiation of KN-3 cells, whereas an antagonist of D1-like receptors and a PKA signaling blocker, inhibited such differentiation. However, antagonists of D2-like receptors promoted differentiation. These results suggested that DA in preodontoblasts and odontoblasts might promote odontoblastic differentiation through D1-like receptors, but not D2-like receptors, and PKA signaling in an autocrine or paracrine manner and plays roles in dentinogenesis. © 2019 Wiley Periodicals, Inc.


    Shoko Fujino, Sayuri Hamano, Atsushi Tomokiyo, Tomohiro Itoyama, Daigaku Hasegawa, Hideki Sugii, Shinichiro Yoshida, Ayako Washio, Aoi Nozu, Taiga Ono, Naohisa Wada, Chiaki Kitamura, Hidefumi Maeda. Expression and function of dopamine in odontoblasts. Journal of cellular physiology. 2020 May;235(5):4376-4387

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 31612496

    View Full Text