Reversible black tongue: A little known side effect of imipenem/cilastatin and evidence for novel mode of action.

Black tongue syndrome (BT) is a rare and self-limiting disorder which can result from physiological and metabolic condition and ingestion of toxic substances. Medications are the most common cause of BT. A 39-year-old male patient presented with BT after the initiation of imipenem/cilastatin. Within one week of cessation of these drugs, the patient's tongue returned to a normal colour. This is the first case of BT induced by imipenem/cilastatin. Withdrawal of the combination is likely to reverse the condition. © 2019 John Wiley & Sons Ltd.

Citation

Shujuan Zhao, Lei Fan, Jing Feng, Peizhi Ma. Reversible black tongue: A little known side effect of imipenem/cilastatin and evidence for novel mode of action. Journal of clinical pharmacy and therapeutics. 2020 Apr;45(2):370-372

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PMID: 31621928

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