c-Myc controls the fate of neural progenitor cells during cerebral cortex development.

The anatomical structure of the mammalian cerebral cortex is the essential foundation for its complex neural activity. This structure is developed by proliferation, differentiation, and migration of neural progenitor cells (NPCs), the fate of which is spatially and temporally regulated by the proper gene. This study was used in utero electroporation and found that the well-known oncogene c-Myc mainly promoted NPCs' proliferation and their transformation into intermediate precursor cells. Furthermore, the obtained results also showed that c-Myc blocked the differentiation of NPCs to postmitotic neurons, and the expression of telomere reverse transcriptase was controlled by c-Myc in the neocortex. These findings indicated c-Myc as a key regulator of the fate of NPCs during the development of the cerebral cortex. © 2019 Wiley Periodicals, Inc.

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Xiu-Li Wang, Yan-Xia Ma, Ren-Jie Xu, Jin-Jin Ma, Hong-Cheng Zhang, Shi-Bin Qi, Jin-Hui Xu, Xu-Zhen Qin, Hao-Nan Zhang, Chang-Mei Liu, Jian-Quan Chen, Bin Li, Hui-Lin Yang, Saijilafu. c-Myc controls the fate of neural progenitor cells during cerebral cortex development. Journal of cellular physiology. 2020 Apr;235(4):4011-4021

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PMID: 31625158

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