Langerhans Cells Spy on Keratinocytes.

Tunneling nanotubes (TNTs) have been described as a novel mechanism for intercellular communication. However, the ability of epidermal cells to utilize TNTs remains a mystery. In this issue, Su and Igyártó (2019) showed that Langerhans cells (LCs) obtain mRNA from keratinocytes (KC) in vivo presumably via TNTs. The demonstration of exchange of genetic material from KC to LC in vivo is an an unexpected method of antigen acquisition by LC and also an important consideration when analyzing transcriptomic data. Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Jacinto S De La Cruz Diaz, Daniel H Kaplan. Langerhans Cells Spy on Keratinocytes. The Journal of investigative dermatology. 2019 Nov;139(11):2260-2262

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PMID: 31648687

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