Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Gram-negative bacteria belonging to the genus Klebsiella are important nosocomial pathogens, readily acquiring resistance to all known antibiotics. Bacteriocins, non-antibiotic antibacterial proteins, have been earlier proposed as potential therapeutic agents for control of other Gram-negative species such as Escherichia, Pseudomonas and Salmonella. This study is the first report describing pore-forming and peptidoglycan-degrading bacteriocins klebicins from Klebsiella. We have identified, cloned, expressed in plants and characterized nine pore-forming and peptidoglycan-degrading bacteriocins from different Klebsiella species. We demonstrate that klebicins can be used for broad and efficient control of 101 of the 107 clinical isolates representing five Klebsiella species, including multi-drug resistant pathovars and pathovars resistant to carbapenem antibiotics.


Erna Denkovskienė, Šarūnas Paškevičius, Audrius Misiūnas, Benita Stočkūnaitė, Urtė Starkevič, Astra Vitkauskienė, Simone Hahn-Löbmann, Steve Schulz, Anatoli Giritch, Yuri Gleba, Aušra Ražanskienė. Broad and Efficient Control of Klebsiella Pathogens by Peptidoglycan-Degrading and Pore-Forming Bacteriocins Klebicins. Scientific reports. 2019 Oct 28;9(1):15422

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 31659220

View Full Text