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A 2-month-old girl with conjugated hyperbilirubinemia was found at the surgery and by computed tomography to have a large mass originating in the pancreas. Histopathology, molecular testing, and staging evaluations showed this to be a stage 3, MYCN unamplified, intermediate-risk neuroblastoma. The patient had a partial response to risk-stratified chemotherapy. The mass remained unresectable, but the response was sustained after 18 months. Although fewer than a dozen cases of primary pancreatic neuroblastoma have been reported, our experience and a literature review suggest that these tumors can be managed in the same way as similar-risk neuroblastoma of other sites.


Zachary D Morrison, Yeping Sun, Michelle Manalang, Kathleen Dominguez. Primary Pancreatic Neuroblastoma in an Infant. Journal of pediatric hematology/oncology. 2020 Aug;42(6):e541-e543

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PMID: 31688624

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