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    Amoeba proteus is possibly the best known of all unicellular eukaryotes. At the same time, several quintessential issues of its biology, including some aspects of the cell cycle, remain unsolved. Here, we show that this obligate agamic amoebae and related species have a special type of cyclic polyploidy. Their nucleus has an euploid status only for a small fraction of the cell cycle, during metaphase and telophase. The rest of the time it has an aneuploid status, which is a consequence of polyploidization. Extrusion of "excess" chromatin from the nucleus in late interphase and during prophase results in depolyploidization. Such a strategy of life cycle in unicellular eukaryotes is thought to be the main mechanism of "resetting" the Muller's ratchet and is a satisfactory alternative to the meiotic recombination for agamic protists. © 2019 International Society of Protistologists.


    Andrew V Goodkov, Mariia A Berdieva, Yuliya I Podlipaeva, Sergei Yu Demin. The Chromatin Extrusion Phenomenon in Amoeba proteus Cell Cycle. The Journal of eukaryotic microbiology. 2020 Mar;67(2):203-208

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    PMID: 31691412

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