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A new C-linked chalcone-dihydrochalcone dimer, named dracidione, was isolated from the ethyl acetate extract of dragon's blood resin of Dracaena cinnabari Balf. f. Structure elucidation of the new compound was carried out by means of one- and two-dimensional NMR spectroscopy in addition to high resolution mass spectrometry. The unique structure incorporated a chalcone and a dihydrochalcone, which is reported for the first time from nature. Furthermore, dracidione showed moderate α-glucosidase inhibitory activity with IC50= 40.27 µg/ml.


Iman E Helal, Marwa Elsbaey, Ahmed M Zaghloul, El-Sayed S Mansour. A unique C-linked chalcone-dihydrochalcone dimer from Dracaena cinnabari resin. Natural product research. 2021 Aug;35(15):2558-2563

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PMID: 31696735

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