Netrin Synergizes Signaling and Adhesion through DCC.

Rob Meijers, Robert G Smock, Yan Zhang, Jia-Huai Wang

Trends in biochemical sciences 2020 Jan

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Netrin is a prototypical axon guidance cue. Structural studies have revealed how netrin interacts with the deleted in colorectal cancer (DCC) receptor, other receptors, and co-factors for signaling. Recently, genetic studies suggested that netrin is involved in neuronal haptotaxis, which requires a reversible adhesion process. Structural data indicate that netrin can also mediate trans-adhesion between apposing cells decorated with its receptors on the condition that the auxiliary guidance cue draxin is present. Here, we propose that netrin is involved in conditional adhesion, a reversible and localized process that can contribute to cell adhesion and migration. We suggest that netrin-mediated adhesion and signaling are linked, and that local environmental factors in the ventricular zone, the floor plate, or other tissues coordinate its function. Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

Citation

Rob Meijers, Robert G Smock, Yan Zhang, Jia-Huai Wang. Netrin Synergizes Signaling and Adhesion through DCC. Trends in biochemical sciences. 2020 Jan;45(1):6-12