Knee Buckling (Negative Myoclonus) Associated With Clozapine: Reports on 3 Cases.

Özcan Uzun, Abdullah Bolu, Azize Beril Taşçi, Begüm Oğur

Clinical neuropharmacology 2020 Jan/Feb

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Negative myoclonus is rarely seen in the clinical setting. It can be involved in some central nervous system pathologies. It has also been observed after antipsychotic treatment. In this article, we will present 3 cases diagnosed with negative myoclonus in a 120-bed university-affiliated hospital within the past 7 years. Based on our clinical experience, it was observed that myoclonic jerk was a rare condition that started with suddenly dose changes. Patients showed good improvement in response to dose reduction. Since the number of reported cases on negative myoclonus is limited, there is still a lack of well-established consensus on the management of this disease. It can be concluded that myoclonic jerk may be dose-dependent, sudden dose changes may be effective, anticonvulsants are not effective in all cases, and treatment can be achieved by reducing the dose.

Citation

Özcan Uzun, Abdullah Bolu, Azize Beril Taşçi, Begüm Oğur. Knee Buckling (Negative Myoclonus) Associated With Clozapine: Reports on 3 Cases. Clinical neuropharmacology. 2020 Jan/Feb;43(1):26-27