Correlation Engine 2.0
Clear Search sequence regions


  • humans (1)
  • hydrogen (2)
  • hydroxyl (1)
  • MAO- B (4)
  • phenols (4)
  • products (2)
  • quinones (4)
  • Sizes of these terms reflect their relevance to your search.

    Twenty-seven natural product-like polyprenylated phenols and quinones were synthesized and their neuroprotective activity was tested using human monoamine oxidase B (MAO-B) and SH-SY5Y cells. Eight compounds inhibited MAO-B (IC50 values < 25 μM) and the inhibition mode and molecular docking of two (8c and 16c) were investigated. Compounds inhibiting MAO-B activity were additionally tested for their ability to protect SH-SY5Y cells from peroxide injury. Three derivatives (3c, 8c and 16c) exhibited both MAO-B inhibitory and neuroprotective activity. A structure activity-relationship study showed that a phenolic hydroxyl group and a longer side chain are important for both activities. Copyright © 2019 Elsevier Ltd. All rights reserved.

    Citation

    Hitoshi Kamauchi, Takumi Oda, Kanayo Horiuchi, Koichi Takao, Yoshiaki Sugita. Synthesis of natural product-like polyprenylated phenols and quinones: Evaluation of their neuroprotective activities. Bioorganic & medicinal chemistry. 2020 Jan 01;28(1):115156

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 31740200

    View Full Text