The Role of Xenobiotics and Trace Metals in Parkinson's Disease.

Geir Bjørklund, Maryam Dadar, Salvatore Chirumbolo, Jan Aaseth

Molecular neurobiology 2020 Mar

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Research on the etiopathogenesis of Parkinson's disease (PD) has in the very recent years earned many insightful cues about the involvement of xenobiotics and metal pollutants in the onset and exacerbation of this neurodegenerative disorder. Furthermore, particularly for metal pollutants, the hypothesis about the role exerted by impaired mitochondrial function is gaining a leading causative role. In this review, we outline the role of environmental pollution in the pathogenesis of PD, as the prolonged exposure to xenobiotics may account for the majority of PD reported cases, expanding the debate also about some suggested therapeutic approaches.

Citation

Geir Bjørklund, Maryam Dadar, Salvatore Chirumbolo, Jan Aaseth. The Role of Xenobiotics and Trace Metals in Parkinson's Disease. Molecular neurobiology. 2020 Mar;57(3):1405-1417