Hypnotics with novel modes of action.

Daniel Hoyer, Andrew Allen, Laura H Jacobson

British journal of clinical pharmacology 2020 Feb

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Insomnia and, more generally, lack of sleep are on the rise. Traditionally treated by classical hypnotics, such as benzodiazepines and Z drugs, which both act on the GABAA receptor, and other modalities, including nondrug therapies, such as cognitive behavioural therapy, there is a range of new hypnotics which are being developed or have recently received market approval. Suvorexant and the like target the orexin/hypocretin system: they should have less side effects in terms of drug-drug interactions with e.g. alcohol, less memory impairment and dependence potential compared to classical hypnotics. © 2019 The British Pharmacological Society.

Citation

Daniel Hoyer, Andrew Allen, Laura H Jacobson. Hypnotics with novel modes of action. British journal of clinical pharmacology. 2020 Feb;86(2):244-249