The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C.

Alison E Twelvetrees, Flavie Lesept, Erika L F Holzbaur, Josef T Kittler

Journal of cell science 2019 Dec 13

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Binding of motor proteins to cellular cargoes is regulated by adaptor proteins. HAP1 and GRIP1 are kinesin-1 adaptors that have been implicated individually in the transport of vesicular cargoes in the dendrites of neurons. We find that HAP1a and GRIP1 form a protein complex in the brain, and co-operate to activate the kinesin-1 subunit KIF5C in vitro Based upon this co-operative activation of kinesin-1, we propose a modification to the kinesin activation model that incorporates stabilisation of the central hinge region known to be critical to autoinhibition of kinesin-1. © 2019. Published by The Company of Biologists Ltd.

Citation

Alison E Twelvetrees, Flavie Lesept, Erika L F Holzbaur, Josef T Kittler. The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C. Journal of cell science. 2019 Dec 13;132(24)