Review of cobalamin status and disorders of cobalamin metabolism in dogs.

Stefanie Kather, Niels Grützner, Peter H Kook, Franziska Dengler, Romy M Heilmann

Journal of veterinary internal medicine 2020 Jan

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Disorders of cobalamin (vitamin B12 ) metabolism are increasingly recognized in small animal medicine and have a variety of causes ranging from chronic gastrointestinal disease to hereditary defects in cobalamin metabolism. Measurement of serum cobalamin concentration, often in combination with serum folate concentration, is routinely performed as a diagnostic test in clinical practice. While the detection of hypocobalaminemia has therapeutic implications, interpretation of cobalamin status in dogs can be challenging. The aim of this review is to define hypocobalaminemia and cobalamin deficiency, normocobalaminemia, and hypercobalaminemia in dogs, describe known cobalamin deficiency states, breed predispositions in dogs, discuss the different biomarkers of importance for evaluating cobalamin status in dogs, and discuss the management of dogs with hypocobalaminemia. © 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

Citation

Stefanie Kather, Niels Grützner, Peter H Kook, Franziska Dengler, Romy M Heilmann. Review of cobalamin status and disorders of cobalamin metabolism in dogs. Journal of veterinary internal medicine. 2020 Jan;34(1):13-28