Correlation Engine 2.0
Clear Search sequence regions


  • apoptosis (1)
  • brain (5)
  • cell death (1)
  • Heat shock proteins (11)
  • HSPs 70 (1)
  • humans (1)
  • injuries (1)
  • ischemia (3)
  • stroke (1)
  • therapies (1)
  • trauma (1)
  • Sizes of these terms reflect their relevance to your search.

    Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addition to their ability to prevent protein denaturation and aggregation, the HSPs have also been shown to modulate many signaling pathways. Among HSPs, the inducible 70‚ÄČkDa HSP (HSP70) has especially been shown to improve neurological outcome in experimental models of brain ischemia and injury. HSP70 can modulate various aspects of the programmed cell death pathways and inflammation. This review will focus on potential mechanisms of the neuroprotective effects of HSP70 in stroke and brain trauma models. We also comment on potential ways in which HSP70 could be translated into clinical therapies. Published by Elsevier B.V.

    Citation

    Jong Youl Kim, Ji Won Kim, Midori A Yenari. Heat shock protein signaling in brain ischemia and injury. Neuroscience letters. 2020 Jan 10;715:134642

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 31759081

    View Full Text