Rifabutin Is Active against Mycobacterium abscessus in Mice.

Thomas Dick, Sung Jae Shin, Won-Jung Koh, Véronique Dartois, Martin Gengenbacher

Antimicrobial agents and chemotherapy 2020 Jan 27

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There is no reliable cure for Mycobacterium abscessus lung disease. Rifampin is not used clinically due to poor in vitro potency. In contrast, we have shown that rifabutin, another approved rifamycin used to treat tuberculosis, is potent in vitro against M. abscessus Here, we report that rifabutin is as active as clarithromycin against M. abscessus K21 in NOD.CB17-Prkdcscid/NCrCrl mice. This suggests that rifabutin should be considered a repurposing candidate for patients with M. abscessus disease. Copyright © 2020 Dick et al.

Citation

Thomas Dick, Sung Jae Shin, Won-Jung Koh, Véronique Dartois, Martin Gengenbacher. Rifabutin Is Active against Mycobacterium abscessus in Mice. Antimicrobial agents and chemotherapy. 2020 Jan 27;64(2)