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We experienced a case of very early-onset REM sleep behavior disorder (RBD) with ADHD. This case showed typical RBD symptoms with REM sleep without atonia on polysomnography. Methylphenidate, which enhances the dopamine system, attenuated his ADHD symptoms but not RBD symptoms. We speculate that the dysfunction of the laterodorsal tegmental nucleus in the pontine was responsible for the symptoms of RBD and ADHD in this case. Very early-onset RBD is rare, and its profile is not well known. ADHD with dysfunction in the laterodorsal tegmental nucleus may form asubtype of ADHD that is commonly comorbid with very early-onset RBD.


Shunsuke Takagi, Yoshihiro Yamashiro, Genichi Sugihara, Hidehiko Takahashi, Masato Matsuura. Very early-onset of RBD with ADHD: a case report study. Neurocase. 2020 Feb;26(1):60-63

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PMID: 31777313

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