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    Neodymium (Nd3+ )-sensitized nanoconstructs have gained increasing attention in recent decades due to their unique properties, especially optical properties. The design of various Nd3+ -sensitized nanosystems is expected to contribute to medical and health applications, due to their advantageous properties such as high penetration depth, excellent photostability, non-photobleaching, low cytotoxicity, etc. However, the low conversion efficiency and potential long-term toxicity of Nd3+ -sensitized nanoconstructs are huge obstacles to their clinical translations. This review article summarizes three energy transfer pathways of all kinds of Nd3+ -sensitized nanoconstructs focusing on the properties of Nd3+ ions and discusses their recent potential applications as near-infrared (NIR) enabled photomedicine. This review article will contribute to the design and fabrication of novel Nd3+ -sensitized nanoconstructs for NIR-enabled photomedicine, aiming for potentially safer and more efficient designs to get closer to clinical usage. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


    Zhongzheng Yu, Wen Kiat Chan, Timothy Thatt Yang Tan. Neodymium-Sensitized Nanoconstructs for Near-Infrared Enabled Photomedicine. Small (Weinheim an der Bergstrasse, Germany). 2020 Jan;16(1):e1905265

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    PMID: 31782909

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