ALK-negative anaplastic large cell lymphoma with "Hodgkin-like" cytomorphology and nuclear expression of PAX5.

Stefano Fratoni, Pasquale Niscola, Xiangfeng Frank Zhao, Luigi Maria Larocca, Anna Capalbo, Maria Fabbretti, Laura Bernardini, Elisabetta Abruzzese

Pathology, research and practice 2020 Feb

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Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking "Hodgkin-like" cytomorphology and a very uncommon nuclear expression of PAX5. Copyright © 2019. Published by Elsevier GmbH.

Citation

Stefano Fratoni, Pasquale Niscola, Xiangfeng Frank Zhao, Luigi Maria Larocca, Anna Capalbo, Maria Fabbretti, Laura Bernardini, Elisabetta Abruzzese. ALK-negative anaplastic large cell lymphoma with "Hodgkin-like" cytomorphology and nuclear expression of PAX5. Pathology, research and practice. 2020 Feb;216(2):152724