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    Effective messenger RNA (mRNA) transfection in hard-to-transfect cells delivered by vectors is a long-standing challenge. Now it is hypothesized that the high intracellular glutathione level is associated with suppressed mRNA translation. This theory leads to a new design principle of next-generation mRNA vectors: nanoparticles with glutathione depletion chemistry upregulate mRNA translation and enhance transfection, which is beneficial for mRNA delivery in hard-to-transfect cells in vitro and in vivo. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


    Yue Wang, Jie Tang, Yannan Yang, Hao Song, Jianye Fu, Zhengying Gu, Chengzhong Yu. Functional Nanoparticles with a Reducible Tetrasulfide Motif to Upregulate mRNA Translation and Enhance Transfection in Hard-to-Transfect Cells. Angewandte Chemie (International ed. in English). 2020 Feb 10;59(7):2695-2699

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    PMID: 31820548

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