CMIP promotes Herceptin resistance of HER2 positive gastric cancer cells.

Ru Xiang, Xiaowen Han, Keshuo Ding, Zhengsheng Wu

Pathology, research and practice 2020 Feb

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Gastric cancer remains one of the most malignant human cancers with poor prognosis. Herceptin is a well-received antibody drug for HER2 positive gast ric cancer. Primary Herceptin resistance and acquired Herceptin resistance retarded the use of Herceptin for gastric cancer. We herein reported CMIP (C-Maf-inducing protein) was overexpressed in Herceptin-resistant gastric cancer cells MKN45-HR and NCI-N87-HR; CMIP promoted Herceptin resistance of HER2 positive gastric cancer cells. SOX2 was examined to be positively regulated by CMIP and also promoted Herceptin resistance of HER2 positive gastric cancer cells. SOX2 might mediate the Herceptin resistance promoting role of CMIP in gastric cancer cells. Elevated expression of CMIP was associated with poor clinicopathological features including tumor size, lymph node metastasis and clinical stage in HER2 positive gastric cancer patients. Inhibitors of CMIP could be used as potential adjuvant therapeutic drugs for HER2 positive gast ric cancer. Copyright © 2019 Elsevier GmbH. All rights reserved.

Citation

Ru Xiang, Xiaowen Han, Keshuo Ding, Zhengsheng Wu. CMIP promotes Herceptin resistance of HER2 positive gastric cancer cells. Pathology, research and practice. 2020 Feb;216(2):152776