The Actin-Capping Protein Alpha-Adducin Is Required for T-Cell Costimulation.

Timothy J Thauland, Humza A Khan, Manish J Butte

Frontiers in immunology 2019

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Alpha-adducin (Add1) is a critical component of the actin-spectrin network in erythrocytes, acting to cap the fast-growing, barbed ends of actin filaments, and recruiting spectrin to these junctions. Add1 is highly expressed in T cells, but its role in T-cell activation has not been examined. Using a conditional knockout model, we show that Add1 is necessary for complete activation of CD4+ T cells in response to low levels of antigen but is dispensable for CD8+ T cell activation and response to infection. Surprisingly, costimulatory signals through CD28 were completely abrogated in the absence of Add1. This study is the first to examine the role of actin-capping in T cells, and it reveals a previously unappreciated role for the actin cytoskeleton in regulating costimulation. Copyright © 2019 Thauland, Khan and Butte.

Citation

Timothy J Thauland, Humza A Khan, Manish J Butte. The Actin-Capping Protein Alpha-Adducin Is Required for T-Cell Costimulation. Frontiers in immunology. 2019;10:2706