Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques

The results of the RV144 trial demonstrated that vaccination could prevent HIV transmission in humans and that longevity of anti-Env antibodies may be key to this protection. Efforts to improve upon the prime-boost vaccine regimen used in RV144 have indicated that booster immunizations can increase serum anti-Env antibody titers but only transiently. Poor antibody durability hampers efforts to develop an effective HIV-1 vaccine. This study was designed to identify the specific elements involved in the immunological mechanism necessary to produce robust HIV-1-specific antibodies in rhesus macaques. By clearly defining immune-mediated pathways that improve the magnitude and functionality of the anti-HIV-1 antibody response, we will have the foundation necessary for the rational development of an HIV-1 vaccine.

Citation

Anil Verma, Brian A. Schmidt, Sonny R. Elizaldi, Nancy K. Nguyen, Korey A. Walter, Zoltan Beck, Hung V. Trinh, Ashok R. Dinasarapu, Yashavanth Shaan Lakshmanappa, Niharika N. Rane, Gary R. Matyas, Mangala Rao, Xiaoying Shen, Georgia D. Tomaras, Celia C. LaBranche, Keith A. Reimann, David H. Foehl, Johannes S. Gach, Donald N. Forthal, Pamela A. Kozlowski, Rama R. Amara, Smita S. Iyer, Frank Kirchhoff. Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques Journal of Virology. 2020 Feb 28;94(6)

PMID: 31827000

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