INO80 and SWR1 complexes: the non-identical twins of chromatin remodelling.

Oliver Willhoft, Dale B Wigley

Current opinion in structural biology 2020 Apr

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The INO80 family of chromatin remodellers are multisubunit complexes that perform a variety of tasks on nucleosomes. Family members are built around a heterohexamer of RuvB-like protein, an ATP-dependent DNA translocase,nuclear actin and actin-related proteins, and a few complex-specific subunits. They modify chromatin in a number of ways including nucleosome sliding and exchange of variant histones. Recent structural information on INO80 and SWR1 complexes has revealed similarities in the basic architecture of the complexes. However, structural and biochemical data on the complexes bound to nucleosomes reveal these similarities to be somewhat superficial and their biochemical activities and mechanisms are very different. Consequently, the INO80 family displays a surprising diversity of function that is based upon a similar structural framework. Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Citation

Oliver Willhoft, Dale B Wigley. INO80 and SWR1 complexes: the non-identical twins of chromatin remodelling. Current opinion in structural biology. 2020 Apr;61:50-58