PET/computed tomography shows association between subjective pain in knee joints and fluorine-18-fluorodeoxyglucose uptake.

Toshihiko Kamasaki, Keisuke Mori, Yasuyuki Taira, Makiko Orita, Izumi Miyamoto, Toshiya Usui, Kenya Chiba, Takashi Kudo, Noboru Takamura

Nuclear medicine communications 2020 Mar

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The aim of this study was to evaluate the capability of fluorine-18-fluorodeoxyglucose (F-FDG)-PET/computed tomography (CT) in screening for musculoskeletal inflammation and injury in the knee region. The study included 12 subjects (6 men and 6 women) who complained of knee pain at rest and 94 controls who did not. Maximum standardized uptake value (SUV)max was calculated for the right and left knees and compared via a 4-point numerical rating scale (NRS) for subjective knee pain. Correlations between SUV values were also evaluated. SUVmax was significantly higher in knee joints with resting and/or walking pain than in pain-free knee joints. SUVmax in knee joints with walking pain were significantly correlated with NRS category (β = 0.129, P < 0.001). F-FDG-PET/CT may be useful in screening for musculoskeletal inflammation and injury in the knee region. As knee pain is common, especially among elderly individuals, we should consider conducting further examinations when F-FDG uptake is identified in knee joints.

Citation

Toshihiko Kamasaki, Keisuke Mori, Yasuyuki Taira, Makiko Orita, Izumi Miyamoto, Toshiya Usui, Kenya Chiba, Takashi Kudo, Noboru Takamura. PET/computed tomography shows association between subjective pain in knee joints and fluorine-18-fluorodeoxyglucose uptake. Nuclear medicine communications. 2020 Mar;41(3):241-245