BaseSpace
Import Your Data
Literature

FAQ

More FAQs

Back to top
Clear Search sequence regions
(e.g. FXYD4, calcium channel activity, Obesity, Leukocyte, Personalized medicine, Cisplatin)
Bookmark Forward

Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.

Leslie Ratié, Elodie Desmaris, Fernando García-Moreno, Anna Hoerder-Suabedissen, Alexandra Kelman, Thomas Theil, Eric J Bellefroid, Zoltán Molnár

Cerebral cortex (New York, N.Y. : 1991) 2020 May 14


filter terms:
  • birth (1)
  • cell movement (1)
  • Ctip2 (1)
  • culture (1)
  • Dmrt3 (3)
  • DMRT5 (11)
  • Dmrta2 (1)
  • embryo mammalian (1)
  • mab 3 (1)
  • mice (3)
  • mice knockout (1)
  • mitosis (1)
  • neocortex (1)
  • neurogenesis (1)
    • Sizes of these terms reflect their relevance to your search.

    Dmrt5 (Dmrta2) and Dmrt3 are key regulators of cortical patterning and progenitor proliferation and differentiation. In this study, we show an altered apical to intermediate progenitor transition, with a delay in SP neurogenesis and premature birth of Ctip2+ cortical neurons in Dmrt5-/- mice. In addition to the cortical progenitors, DMRT5 protein appears present in postmitotic subplate (SP) and marginal zone neurons together with some migrating cortical neurons. We observed the altered split of preplate and the reduced SP and disturbed radial migration of cortical neurons into cortical plate in Dmrt5-/- brains and demonstrated an increase in the proportion of multipolar cells in primary neuronal cultures from Dmrt5-/- embryonic brains. Dmrt5 affects cortical development with specific time sensitivity that we described in two conditional mice with slightly different deletion time. We only observed a transient SP phenotype at E15.5, but not by E18.5 after early (Dmrt5lox/lox;Emx1Cre), but not late (Dmrt5lox/lox;NestinCre) deletion of Dmrt5. SP was less disturbed in Dmrt5lox/lox;Emx1Cre and Dmrt3-/- brains than in Dmrt5-/- and affects dorsomedial cortex more than lateral and caudal cortex. Our study demonstrates a novel function of Dmrt5 in the regulation of early SP formation and radial cortical neuron migration. Our study demonstrates a novel function of Dmrt5 in regulating marginal zone and subplate formation and migration of cortical neurons to cortical plate. © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.

    Citation

    Leslie Ratié, Elodie Desmaris, Fernando García-Moreno, Anna Hoerder-Suabedissen, Alexandra Kelman, Thomas Theil, Eric J Bellefroid, Zoltán Molnár. Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis. Cerebral cortex (New York, N.Y. : 1991). 2020 May 14;30(5):3296-3312

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 31845734

    View Full Text
    • Copyright © 2025 Illumina Inc. All rights reserved.