Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

With more than 80 subunits, potassium (K+) channels represent a group of ion channels showing high degree of diversity and ubiquity. They play important role in the control of membrane depolarization and cell excitability in several tissues, including the brain. Controlling the intracellular and extracellular K+ flow in cells, they also modulate the hormone and neurotransmitter release, apoptosis and cell proliferation. It is therefore not surprising that an improper functioning of K+ channels in neurons has been associated with pathophysiology of a wide range of neurological disorders, especially Alzheimer's disease (AD). This review aims to give a comprehensive overview of the basic properties and pathophysiological functions of the main classes of K+ channels in the context of disease processes, also discussing the progress, challenges and opportunities to develop drugs targeting these channels as potential pharmacological approach for AD treatment. Copyright © 2019 Elsevier B.V. All rights reserved.


Chiara Villa, Huriye Suphesiz, Romina Combi, Enes Akyuz. Potassium channels in the neuronal homeostasis and neurodegenerative pathways underlying Alzheimer's disease: An update. Mechanisms of ageing and development. 2020 Jan;185:111197

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 31862274

View Full Text