Correlation Engine 2.0
Clear Search sequence regions


  • amino acids (8)
  • humans (1)
  • Sizes of these terms reflect their relevance to your search.

    Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic amino acids. Such amino acids are generated in specialized metabolic pathways. In these pathways, diverse biosynthetic transformations, ranging from isomerizations to the stereospecific functionalization of C-H bonds, are employed to generate structural diversity. The resulting nonproteinogenic amino acids can be integrated into more complex natural products. Here we review recently discovered biosynthetic routes to freestanding nonproteinogenic α-amino acids, with an emphasis on work reported between 2013 and mid-2019.

    Citation

    Jason B Hedges, Katherine S Ryan. Biosynthetic Pathways to Nonproteinogenic α-Amino Acids. Chemical reviews. 2020 Mar 25;120(6):3161-3209

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 31869221

    View Full Text