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    Skeletal muscle is the largest organ system in the mammalian body and plays a key role in locomotion of horses. Fast and slow muscle fibers have different abilities and functions to adapt to exercises. To investigate the RNA and miRNA expression profiles in the muscles with different muscle fiber compositions on Mongolian horses. We examined the muscle fiber type population and produced deep RNA sequencing for different parts of skeletal muscles. And chose two of them with the highest difference in fast and slow muscle fiber population (splenius and gluteus medius) for comparing the gene expression profile of slow and fast muscle fiber types. We identified a total of 275 differentially expressed genes (DEGs), and 11 differentially expressed miRNAs (DEmiRs). In addition, target gene prediction and alternative splicing analysis were also performed. Significant correlations were found between the differentially expressed gene, miRNAs, and alternative splicing events. The result indicated that differentially expressed muscle-specific genes and target genes of miRNAs might co-regulating the performance of slow and fast muscle fiber types in Mongolian horses. Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.


    Tugeqin Bao, Haige Han, Bei Li, Yiping Zhao, Gerelchimeg Bou, Xinzhuang Zhang, Ming Du, Ruoyang Zhao, Togtokh Mongke, Laxima, Wenqi Ding, Zijie Jia, Manglai Dugarjaviin, Dongyi Bai. The distinct transcriptomes of fast-twitch and slow-twitch muscles in Mongolian horses. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 2020 Mar;33:100649

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    PMID: 31869634

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