Synthesis of NickFects, a New Family of CPPs, by Solid-Phase Peptide Synthesis.

Piret Arukuusk, Ülo Langel

Methods in molecular biology (Clifton, N.J.) 2020

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Cell-penetrating peptides (CPPs) are relatively short peptides that can enter to the cell interior and facilitate intracellular delivery of associated cargo molecules. NickFects is a novel family of CPPs, designed to deliver various types of bio-active cargos using non-covalent nanoparticle formation approach. This chapter describes in details the manual synthesis of cell-penetrating peptides using Fmoc-solid phase peptide synthesis (SPPS).

Citation

Piret Arukuusk, Ülo Langel. Synthesis of NickFects, a New Family of CPPs, by Solid-Phase Peptide Synthesis. Methods in molecular biology (Clifton, N.J.). 2020;2103:239-247