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Although return of function has been reported in patients undergoing proximal forearm transplantations (PFTs), reports of long-term function are limited. In this study, we evaluated the clinical progress and function 7 years postoperatively in a patient who underwent bilateral PFT. A 58-year-old man underwent bilateral PFT in May 2012. Transplantation involved all of the flexor and extensor muscles of the forearm. Neurorrhaphies of the median, ulnar, and radial nerves were epineural and 7 cm proximal to the elbow. Immunosuppressive maintenance medications during the first 3 years postoperatively were tacrolimus, mycophenolate, and steroids, and later, tacrolimus, sirolimus, and steroids. Forearm function was evaluated annually using the Disabilities of the Arm, Shoulder, and Hand; Carroll; Hand Transplantation Score System; Short Form-36; and Kapandji scales. We also evaluated his grip and pinch force. Postoperatively, the patient developed hypertriglyceridemia and systemic hypertension. He experienced 6 acute rejections, and none were resistant to steroids. Motor function findings in his right/left hand were: grip strength: 10/13 kg; key pinch: 3/3 kg; Kapandji score: 6/9 of 10; Carroll score: 66/80; Hand Transplantation Score System score: 90/94. His preoperative Disabilities of the Arm, Shoulder, and Hand score was 50 versus 18, postoperatively; his Short Form-36 score was 90. This function improved in relation with the function reported in the second year. Seven years following PFT, the patient gained limb strength with a functional elbow and wrist, although with diminished digital dexterity and sensation. Based on data presented by other programs and our own experience, PFT is indicated for select patients.


Martín Iglesias, Eliezer Villanueva-Castro, Julio Macias-Gallardo, Josefina Alberú-Gómez, Rafael P Leal-Villalpando, Jorge Zamudio-Bautista, Victor Acosta, Patricia Butrón, Juan G Sierra-Madero, Jennifer Cuellar-Rodriguez, Verónica Espinosa-Cruz, Claudia Gómez-Camargo, Mariana Mayorquín-Ruiz, Jorge Vázquez-Lamadrid, Sonia Toussaint-Caire, Judith Domínguez-Cherit, Joel Dorantes-García, Janette Furuzawa-Carballeda, Carlos R Hernandez-Castillo, Juan M Guzmán González, Natalia Castelan-Carmona, Mayra López-Mártinez, Norma González-Tableros, Adriana Arvizu-Hernández, Adrián De Santiago-Zárate. Bilateral Proximal Forearm Transplantation: Case Report at 7 Years. Transplantation. 2020 Apr;104(4):e90-e97

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PMID: 31880751

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