Ying Li, Fanxi Guo, Xiangyuan Jiang, Juncai Ren, Yingxue Miao, Fangyi Ding, Zugong Yu
Journal of veterinary pharmacology and therapeutics 2020 MarThis study aimed to develop one novel meloxicam (MEL) oil suspension for sustained-release and compare the pharmacokinetic characteristics of it with MEL conventional formulation in pigs after a single intramuscular administration. Six healthy pigs were used for the study by a crossover design in two periods with a withdrawal interval of 14 days. Plasma concentrations of MEL were measured by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Pharmacokinetic parameters were calculated by noncompartmental methods. The difference was statistically significant (p < .05) between MEL oil suspension and MEL conventional formulation in pharmacokinetic parameters of mean residence time (6.16 ± 4.04) hr versus (2.66 ± 0.55) hr, peak plasma concentration (Cmax ) (0.82 ± 0.12) µg/ml versus (1.12 ± 0.22) µg/ml, time needed to reach Cmax (Tmax ) (2.33 ± 0.82) hr versus (0.59 ± 0.18) hr, and terminal elimination half-life (t1/2λz ) (3.74 ± 2.66) hr versus (1.55 ± 0.37) hr. The mean area under the concentration-time curve (AUC0-∝ ) of MEL oil suspension and MEL conventional formulation was 5.35 and 3.43 hr µg/ml, respectively, with a relative bioavailability of 155.98%. Results of the present study demonstrated that the MEL oil suspension could prolong the effective time of drugs in blood, thereby reducing the frequency of administration on a course of treatment. Therefore, the novel MEL oil suspension seems to be of great value in veterinary clinical application. © 2019 John Wiley & Sons Ltd.
Ying Li, Fanxi Guo, Xiangyuan Jiang, Juncai Ren, Yingxue Miao, Fangyi Ding, Zugong Yu. Pharmacokinetics and relative bioavailability of meloxicam oil suspension in pigs after intramuscular administration. Journal of veterinary pharmacology and therapeutics. 2020 Mar;43(2):189-196
PMID: 31880830
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