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Peripherin 2 (also known as RDS/Prph2) is localized to the rims of rod and cone outer segment (OS) discs. The C-terminus of Prph2 is a critical functional domain, but its exact role is still unknown. In this mini review, we describe work on the Prph2 C-terminus, highlighting its role as a regulator of protein trafficking, membrane curvature, ectosome secretion, and membrane fusion. Evidence supports a role for the Prph2 C-terminus in these processes and demonstrates that it is necessary for the initiation of OS morphogenesis.


Shannon M Conley, Muayyad R Al-Ubaidi, Muna I Naash. The Role of the Prph2 C-Terminus in Outer Segment Morphogenesis. Advances in experimental medicine and biology. 2019;1185:495-499

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PMID: 31884660

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