The diagnosis and prognosis values of WNT mRNA expression in colon adenocarcinoma.

Guo-Tian Ruan, Li-Chen Zhu, Yi-Zhen Gong, Xi-Wen Liao, Xiang-Kun Wang, Cun Liao, Shuai Wang, Ling Yan, Hai-Lun Xie, Xin Zhou, Yang-Zi Li, Feng Gao

Journal of cellular biochemistry 2020 Jun

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WNT family genes have participated in the progression and development of many cancers, however, the association between colon adenocarcinoma (COAD) and WNTs have been rarely reported. This study investigated the significance of WNT genes expression in COAD from the standpoint of diagnosis and prognosis. The RNA-sequencing dataset of COAD was downloaded from The Cancer Genome Atlas and University of California, Santa Cruz Xena browser. The biology functions of WNT genes were investigated by biological analysis. Biological analysis of WNT family genes indicated that WNT genes were noticeably enriched in the complex process of WNT signaling pathway. The Pearson correlation analysis suggested WNT1 and WNT9B had a strong correlation. And receiver operating characteristic curves suggested that most of the genes could serve as a significant diagnostic makers in COAD (P < .05), especially WNT2 and WNT7B had high diagnostic values that the area under curve were 0.997 (95% confidence interval [0.994-1.000]) and 0.961 (95%CI [0.939-0.983]), respectively. And our multivariate survival analysis suggested the downregulated of WNT10B (P < .05) showed a favor prognosis in COAD overall survival. And the risk score model predicted that the upregulated expression of WNT10B might increase the risk of death. The very study we had conducted suggested that WNT genes had a certain connection with the diagnosis and prognosis of COAD. The messenger RNA expression of WNT2 and WNT7B might become potentially diagnostic biomarkers, and WNT10B might serve as an independent prognosis indicator for COAD. © 2019 Wiley Periodicals, Inc.

Citation

Guo-Tian Ruan, Li-Chen Zhu, Yi-Zhen Gong, Xi-Wen Liao, Xiang-Kun Wang, Cun Liao, Shuai Wang, Ling Yan, Hai-Lun Xie, Xin Zhou, Yang-Zi Li, Feng Gao. The diagnosis and prognosis values of WNT mRNA expression in colon adenocarcinoma. Journal of cellular biochemistry. 2020 Jun;121(5-6):3145-3161