Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Cellular microRNAs (miRNAs) were identified as a key player in the posttranscriptional regulation of cellular-genes regulatory pathways. They also emerged as a significant regulator of the immune response. In particular, miR-146a acts as an importance modulator of function and differentiation cells of the innate and adaptive immunity. It has been associated with disorder including cancer and viral infections. Given its significance in the regulation of key cellular processes, it is not surprising which virus infection have found ways to dysregulation of miRNAs. miR-146a has been identified in exosomes (exosomal miR-146a). After the exosomes release from donor cells, they are taken up by the recipient cell and probably the exosomal miR-146a is able to modulate the antiviral response in the recipient cell and result in making them more susceptible to virus infection. In this review, we discuss recent reports regarding miR-146a expression levels, target genes, function, and contributing role in the pathogenesis of the viral infection and provide a clue to develop the new therapeutic and preventive strategies for viral disease in the future. © 2019 International Union of Biochemistry and Molecular Biology.


Javid Sadri Nahand, Mohammad Reza Karimzadeh, Maria Nezamnia, Maryam Fatemipour, Alireza Khatami, Sogol Jamshidi, Mohsen Moghoofei, Mohammad Taghizadieh, Sarah Hajighadimi, Alimohammad Shafiee, Mohammad Sadeghian, Farah Bokharaei-Salim, Hamed Mirzaei. The role of miR-146a in viral infection. IUBMB life. 2020 Mar;72(3):343-360

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 31889417

View Full Text