Measles in pregnant women: A systematic review of clinical outcomes and a meta-analysis of antibodies seroprevalence.

Pregnant women represent a category at high risk of severe measles infection, that negatively affects the fetus as well. A systematic review of clinical outcomes of measles infection in gravid subjects and a meta-analysis of antibodies prevalence among pregnant women was conducted. MEDLINE and EMBASE databases were searched up to 18 June 2018. The screening focused on: (i) articles describing the outcome of measles in pregnancy, synthesized in a descriptive fashion; (ii) articles addressing the measles seroprevalence in cohorts of gravid women, analysed quantitatively. Twenty-nine articles met inclusion criteria. A total of 420 cases of measles in gravid subjects were described, from 1941 to 2012. Among women, 18 deaths (4.3%) occurred, and the most frequent complication was pneumonia (75/420, 17.9%). Prematurity was the most important complication concerning fetal outcomes (55 out of 410 cases with available data, 13.4%). The random-effects pooled seroprevalence of measles in 20,546 gravid women worldwide was 89.3% (95% CI: 87.3-91.1%), that decreased, although not in a statistically significant way, over time (p = 0.54). Measles infection in pregnancy is dangerous both for the mother and the foetus. Antibody seroprevalence among gravid women on a global scale is lower than the herd immunity threshold. Copyright © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Citation

Paola Congera, Alberto Enrico Maraolo, Serena Parente, Nicola Schiano Moriello, Vincenzo Bianco, Grazia Tosone. Measles in pregnant women: A systematic review of clinical outcomes and a meta-analysis of antibodies seroprevalence. The Journal of infection. 2020 Feb;80(2):152-160

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PMID: 31891729

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