Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

6-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson's disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species. Its ability to release Fe(II) from protein storage sites also results in the formation of hROS. This account will consider how this family of toxic products may contribute to the observed effects of 6-OHDA.

Citation

Damir VareŇ°lija, Keith F Tipton, Gavin P Davey, Andrew G McDonald. 6-Hydroxydopamine: a far from simple neurotoxin. Journal of neural transmission (Vienna, Austria : 1996). 2020 Feb;127(2):213-230

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 31894418

View Full Text