Templated Collagen "Double Helices" Maintain Their Structure.

I Caglar Tanrikulu, William M Westler, Aubrey J Ellison, John L Markley, Ronald T Raines

Journal of the American Chemical Society 2020 Jan 22

filter terms:

The self-assembly of collagen-mimetic peptides (CMPs) that form sticky-ended triple helices has allowed the production of surprisingly stable artificial collagen fibers and hydrogels. Assembly through sticky ends requires the recognition of a single strand by a templated strand dimer. Although CMPs and their triple helices have been studied extensively, the structure of a strand dimer is unknown. Here, we evaluate the physical characteristics of such dimers, using disulfide-templated (PPG)10 dimers as a model. Such "linked-dimers" retain their collagen-like structure even in the absence of a third strand, but only when their strands are capable of adopting a triple-helical fold. The intrinsic collagen-like structure of templated CMP pairs helps to explain the success of sticky-ended CMP association and changes the conception of new synthetic collagen designs.

Citation

I Caglar Tanrikulu, William M Westler, Aubrey J Ellison, John L Markley, Ronald T Raines. Templated Collagen "Double Helices" Maintain Their Structure. Journal of the American Chemical Society. 2020 Jan 22;142(3):1137-1141