Regulation of CHK1 by the Ubiquitin-Proteasome System.

Maëlle Cartel, Christine Didier

The FEBS journal 2020 May

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The checkpoint kinase 1 (CHK1) is a master regulator of genome integrity in vertebrate cells. Despite its important cell cycle functions, its regulation is still incompletely understood. Cassidy et al. provide novel insights on the regulation of the CHK1 abundance by the HECT E3 ligase HUWE1 during unperturbed cell cycle as well as in response to replicative stress. These results may help us to apprehend the underlying mechanism of tumorigenesis. © 2019 Federation of European Biochemical Societies.