Glycan Array Technology.

Juana Elizabeth Reyes Martinez, Baptiste Thomas, Sabine Lahja Flitsch

Advances in biochemical engineering/biotechnology 2021

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Glycan (or carbohydrate) arrays have become an essential tool in glycomics, providing fast and high-throughput data on protein-carbohydrate interactions with small amounts of carbohydrate ligands. The general concepts of glycan arrays have been adopted from other microarray technologies such as those used for nucleic acid and proteins. However, carbohydrates have presented their own challenges, in particular in terms of access to glycan probes, linker attachment chemistries and analysis, which will be reviewed in this chapter. As more and more glycan probes have become available through chemical and enzymatic synthesis and robust linker chemistries have been developed, the applications of glycan arrays have dramatically increased over the past 10 years, which will be illustrated with recent examples. © 2019. Springer Nature Switzerland AG.

Citation

Juana Elizabeth Reyes Martinez, Baptiste Thomas, Sabine Lahja Flitsch. Glycan Array Technology. Advances in biochemical engineering/biotechnology. 2021;175:435-456