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Three new thiophene derivatives, ecliprostins A-C (1-3), have been isolated from the aerial parts of a Compositae medicinal plant Eclipta prostrata, and structures of them have been elucidated by comprehensive spectroscopic analyses. Both ecliprostins A (1) and B (2) feature an acetylenic bithiophenyl backbone and also incorporate an isovalerate moiety, while ecliprostin C (3) is a symmetrical dimer of compound 1 and represents the first example bonded via an ether bridge among the very limited natural dimers. All three compounds show antibacterial activity against Staphylococcus aureus. Copyright © 2020 Elsevier B.V. All rights reserved.


Shu-Juan Yu, Jin-Hai Yu, Fei He, Jie Bao, Jun-Sheng Zhang, Yin-Yin Wang, Hua Zhang. New antibacterial thiophenes from Eclipta prostrata. Fitoterapia. 2020 Apr;142:104471

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PMID: 31917302

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