Correlation Engine 2.0
Clear Search sequence regions

  • adult (1)
  • blood urea nitrogen (12)
  • cellular (2)
  • china (1)
  • cohort study (1)
  • female (1)
  • humans (1)
  • insulin (2)
  • odds ratios (2)
  • pregnancy (4)
  • pregnant women (2)
  • risk factors (1)
  • urea (1)
  • women (1)
  • Sizes of these terms reflect their relevance to your search.

    Prior studies indicated that urea increased insulin resistance and higher blood urea nitrogen (BUN) was associated with incident diabetes mellitus. However, it remains unclear whether BUN during the first trimester of pregnancy increases risk of gestational diabetes mellitus (GDM). We aimed to investigate the association between first-trimester BUN and risk of incident GDM. We conducted a prospective, multicenter cohort study of pregnant women. A total of 13 448 eligible pregnant women with measured first-trimester BUN levels were included in this analysis. Logistic regression analysis was used to estimate the relationship between BUN and GDM. Discrimination and reclassification for GDM by BUN were analysed. A total of 2973 (22.1%) women developed GDM. Compared with the lowest quartile of BUN, the third and fourth quartiles were associated with increased risk of GDM (adjusted odds ratios 1.21 [95% CI 1.07-1.37] and 1.50 [95% CI 1.33-1.69], respectively, P for trend <.001). The addition of BUN to conventional factor model improved discrimination (C statistic 0.2%, P = .003) and reclassification (net reclassification index 14.67%, P < .001; integrated discrimination improvement 0.12%, P < .001) for GDM. In conclusion, higher BUN concentrations during the first trimester of pregnancy were associated with increased risk of GDM, suggesting that BUN could be a potential predictor for GDM. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine John Wiley & Sons Ltd.


    Pei Feng, Guangli Wang, Qian Yu, Wei Zhu, Chongke Zhong. First-trimester blood urea nitrogen and risk of gestational diabetes mellitus. Journal of cellular and molecular medicine. 2020 Feb;24(4):2416-2422

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 31925909

    View Full Text