miR-194 relieve neuropathic pain and prevent neuroinflammation via targeting FOXA1.

The emerging role of microRNAs (miRNAs) have been deeply explored in multiple diseases including neuropathic pain. miR-194 was widely reported to be a tumor suppressor and was related to the inflammatory response. The critical role of neuroinflammation on neuropathic pain leads to a thinking about the relationship between miR-194 and neuropathic pain. However, the function of miR-194 in neuropathic pain remains unknown. This study was aimed to explore the relationship between miR-194 and neuropathic pain progression by chronic sciatic nerve injury (CCI). miR-194 abnormally downregulated in the CCI model rat and its overexpression significantly alleviates neuroinflammation in vivo. We predict Forkhead box protein A1 (FOXA1) as a direct target of miR-194, whose restoration can markedly reverse the effects of miR-194 on neuropathic pain. Overall, our study demonstrated a novel mechanism of neuropathic pain progression that miR-194 alleviates neuropathic pain via targeting FOXA1 and preventing neuroinflammation by downregulating inflammatory cytokines containing cyclooxygenase 2, interleukin 6 (IL-6), and IL-10 in vivo, which can be reversed by the overexpression of FOXA1. © 2020 Wiley Periodicals, Inc.

Citation

Xian Zhang, Qiuqing Chen, Jian Shen, Li Wang, Yi Cai, Kai-Run Zhu. miR-194 relieve neuropathic pain and prevent neuroinflammation via targeting FOXA1. Journal of cellular biochemistry. 2020 Jun;121(5-6):3278-3285

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PMID: 31930555

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