Multicentric B-cell lymphoma with presumed paraneoplastic generalized cutaneous sclerosis in a dog.

Verena K Affolter, Danielle O'Brien, Terry M Nagle, Catherine A Outerbridge

Veterinary dermatology 2020 Jun

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Reports of dermal sclerosis in dogs include scleroderma or morphea of unknown cause, cicatricial alopecia and congenital/hereditary fibrosis. A 12-year-old, male castrated chihuahua-mix dog was evaluated for skin lesions of unknown duration. The dog had severe alopecia, skin thickening and marked peripheral lymphadenopathy. Lymph node cytological investigation, immunohistochemical investigation and clonality testing demonstrated an intermediate to large B-cell lymphoma. The thickened skin had severe collagen deposition, effacing adnexal structures. The dog's lymphoma was treated but the skin lesions remained unchanged. The dog was euthanized. To the best of the authors' knowledge, this is the first report of multicentric B-cell lymphoma in a dog with concurrent diffuse cutaneous sclerosis, similar to a human paraneoplastic reaction. © 2019 ESVD and ACVD.

Citation

Verena K Affolter, Danielle O'Brien, Terry M Nagle, Catherine A Outerbridge. Multicentric B-cell lymphoma with presumed paraneoplastic generalized cutaneous sclerosis in a dog. Veterinary dermatology. 2020 Jun;31(3):250-e56