1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature.

Haijun Wang, Yin Shen, Lei Zhao, Youfan Ye

Current medicinal chemistry 2021

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1-Deoxynojirimycin (1-DNJ) is a naturally occurring sugar analogue with unique bioactivities. It is found in mulberry leaves and silkworms, as well as in the metabolites of certain microorganisms, including Streptomyces and Bacillus. 1-DNJ is a potent α-glucosidase inhibitor and it possesses anti-hyperglycemic, anti-obese, anti-viral and anti-tumor properties. Some derivatives of 1-DNJ, like miglitol, miglustat and migalastat, were applied clinically to treat diseases such as diabetes and lysosomal storage disorders. The present review focused on the extraction, determination, pharmacokinetics and bioactivity of 1-DNJ, as well as the clinical application of 1-DNJ derivatives. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Haijun Wang, Yin Shen, Lei Zhao, Youfan Ye. 1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature. Current medicinal chemistry. 2021;28(3):628-643